Research – University of Copenhagen

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Research

With a foundation in chemical synthesis, we seek to explore the function of small molecules, peptides, peptidomimetics, and proteins in biological systems. We are focusing on peptidomimetic secondary structures with potential as antimicrobial agents, as non-proteinogenic ligands for disruption of protein–protein interactions, and for multivalent display. We are also exploring naturally occurring macrocyclic peptides – and analogues thereof – for development of class- or isoform-selective HDAC inhibitors and quorum sensing modulators, as well as investigating substrate-specificity of the human lysine deacylase enzymes using chemical biology tools.

Development of HDAC inhibitors


Investigation of lysine acylation

Foldamers








Methodology and autoinducing peptides