Publications – University of Copenhagen

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M. Bæk, P. Martín-Gago, J. S. Laursen, J. L. H. Madsen, S. Chakladar, C. A. Olsen. Activity-dependent Probes Containing epsilon-N-Thioacyllysine and epsilon-N-Acyl-(delta-aza)lysine Residues. (ChemRxiv 2019, DOI: 10.26434/chemrxiv.10315502).

C. Moreno-Yruela, D. M. Fass, C. Cheng, J. Herz, C. A. Olsen,* S. J. Haggarty*. Kinetic Tuning of HDAC Inhibitors Affords Potent Inducers of Progranulin Expression. ACS Chem. Neurosci. 2019, 10, 3769–3777.

Highlighted by:

P. Peng, M. Baldry, B. H. Gless, M. S. Bojer, C. E. Gonora, S. Baig, P. S. Andersen, C. A. Olsen, H. Ingmer. Effect of Co-inhabiting Coagulase Negative Staphylococci on S. aureus agr Quorum Sensing, Host Factor Binding, and Biofilm Formation. Front. Microbiol. 2019, 10, 2212.

75. B. H. Gless, M. S. Bojer, P. Peng, M. Baldry, H. Ingmer, C. A. Olsen. Identification of Autoinducing Thiodepsipeptides from Staphylococci Enabled by Native Chemical Ligation. Nat. Chem. 2019, 11, 463–469.

Highlighted by:
News & Views Nat. Chem. 2019, 11, 398–399
Behind the Paper
UCPH Health Science, 10 May 2019
Technology Networks, 13 May 2019
Dansk Kemi 2019100 (6), 12–15

. P. Martín-Gago, C. A. Olsen. Arylfluorosulfate-based Electrophiles for Covalent Protein Labeling: A New Addition to the Arsenal. Angew. Chem. Int. Ed. 2019, 58, 957–966. (Minireview)

I. Wellhöfer, K. Frydenvang, S. Kotesova, A. M. Christiansen, J. S. Laursen, C. A. Olsen. Functionalized Helical beta-Peptoids. J. Org. Chem. 2019, 84, 3762–3779(Featured Article)

B. H. Gless, C. A. Olsen. Direct Peptide Cyclization and One-Pot Modification Using the MeDbz Linker. J. Org. Chem. 2018, 83, 10525–10534.

Highlighted in: Synfacts 2019; 15, 0446.

C. Moreno-Yruela, C. A. Olsen. Synthesis of Trifluoromethyl Ketone-Containing Amino Acid Building Blocks for the Preparation of Peptide-Based HDAC Inhibitors. Synthesis-Stuttgart 2018, 50, 4037–4046(Feature Article)

 C. Moreno-Yruela, I. Galleano, A. S. Madsen, C. A. Olsen. Histone Deacetylase 11 is an ε-N-Myristoyllysine Hydrolase. Cell Chem. Biol. 201825, 849–856 (bioRxiv 2017, DOI: 10.1101/211839).

Highlighted by:
UCPH Health Science, 25 July 2018, 26 Jul 2018
eCancer, 26 Jul 2018
BCN News, 2 August 2018
BioWorld Science, 6 August 2018
Futurity, 16 August 2018

S. V. Olesen, N. Rajabi, B. Svensson, C. A. Olsen, A. S. Madsen. An NAD+-Dependent Sirtuin Depropionylase and Deacetylase (Sir2La) From the Probiotic Bacterium Lactobacillus acidophilus NCFM. Biochemistry, 201857, 3903–3915. (bioRxiv 2018, DOI: 10.1101/252379).

68. P. Santner, J. M. da Silva Martins, C. Kampmeyer, R. Hartmann-Petersen, J. S. Laursen, A. Stein, C. A. Olsen, I. T. Arkin, J. R. Winther, M. Willemoës, K. Lindorff-Larsen.Random mutagenesis analysis of the Influenza A M2 proton channel reveals novel resistance mutants. Biochemistry 2018, 57, 5957–5968.

67. P. Santner, J. M. da Silva Martins, J. S. Laursen, L. Behrendt, L. Riber, C. A. Olsen, I. T. Arkin, J. R. Winther, M. Willemoës, K. Lindorff-Larsen.A robust proton flux (pHlux) assay for studying function and inhibition of the Influenza A M2 proton channel. Biochemistry 2018, 57, 5949–5956.

66. N. Rajabi, M. Auth, K. R. Troelsen, M. Pannek, D. P. Bhatt, M. Fontenas, M. D. Hirschey, C. Steegborn, A. S. Madsen, C. A. Olsen. Mechanism-based Inhibitors of the Human Sirtuin 5 Deacylase: Structure–Activity Relationship, Biostructural, and Kinetic Insight. Angew. Chem. Int. Ed. 2017, 56, 14836–14841. (PubMed: PMC Full text)

J. Engel-Andreasen, I. Wellhöfer, K. Wich, C. A. Olsen. Backbone-Fluorinated 1,2,3-Triazole-Containing Dipeptide Surrogates. J. Org. Chem. 2017, 82, 11613–11619.

B. H. Gless, P. Peng, K. D. Pedersen, C. H. Gotfredsen, H. Ingmer, C. A. Olsen. Structure–Activity Relationship Study Based on Auto-Inducing Peptide (AIP) from Dog Pathogen S. schleiferi. Org. Lett. 2017, 19, 5276–5279.

B. Kitir, A. R. Maolanon, R. G. Ohm, A. R. Colaço, P. Fristrup, A. S. Madsen, C. A. Olsen. Chemical Editing of Macrocyclic Natural Products and Kinetic Profiling Reveal Slow, Tight-Binding HDAC Inhibitors with Picomolar Affinities. Biochemistry 2017, 56, 5134–5146.

J.-I. Lai, L. J. Leman, S. Ku, C. J. Vickers, C. A. Olsen, A. Montero, M. R. Ghadiri, J. M. Gottesfeld. Cyclic Tetrapeptide HDAC Inhibitors as Potential Therapeutics for Spinal Muscular Atrophy: Screening with iPSC-derived Neuronal Cells. Bioorg. Med. Chem. Lett. 2017, 27, 3289–3293.

A. R. Maolanon, H. M. E. Kristensen, L. J. Leman, M. R. Ghadiri, C. A. Olsen. Natural and Synthetic Macrocyclic Histone Deacetylase Inhibitors. ChemBioChem 2017, 18, 5–49. (Review).


60. I. Galleano, J. Nielsen, A. S. Madsen, C. A. Olsen. Scalable and Purification-free Synthesis of a Myristoylated Fluorogenic Sirtuin Substrate. Synlett 2017, 28, 2169–2173.

59. K. A. Anderson, A. S. Madsen, C. A. Olsen, M. D. Hirschey. Metabolic Control by Enzymes that Sense NAD+, NADH, and Their Ratio. Biochim. Biophys. Acta Bioenergetics. 2017, 1858, 991–998. (Review).

58. K. A. Anderson, F. K. Huynh, K. Fisher-Wellman, J. D. Stuart, B. S. Peterson, J. D. Douros, G. R. Wagner, J. W. Thompson, A. S. Madsen, M. F. Green, R. M. Sivley, O. R. Ilkayeva, R. D. Stevens, D. S. Backos, J. A. Capra, C. A. Olsen, J. E. Campbell, D. M. Muoio, P. A. Grimsrud, M. D. Hirschey. SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion. Cell Metab. 2017, 25, 838–855.

E. McDonnell, S. B. Crown, D. B. Fox, B. Kitir, O. R. Ilkayeva, C. A. Olsen, P. A. Grimsrud, M. D. Hirschey. Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation. Cell Rep. 2016, 17, 1463–1472.

J. Canovas, M. Baldry, M. S. Bojer, P. S. Andersen, B. H. Gless, P. K. Grzeskowiak, M. Stegger, P. Damborg, C. A. Olsen, H. Ingmer. Cross-talk Between Staphylococcus aureus and other Staphylococcal Species via the agr Quorum Sensing System. Front. Microbiol. 2016, 7, 1733. [Corrections: 2017, 8, 1075 and 20178, 1949]

55. A. R. Maolanon, A. S. Madsen, C. A. Olsen. Innovative Strategies for Selective Inhibition of Histone Deacetylases. Cell Chem. Biol. 2016, 23, 759–768. (Free Featured Article).

A. S. Madsen, C. A. Olsen. Optoepigenetics: An Acetylation Photoswitch. Nat. Chem. Biol. 2016, 12, 306–307. (News & Views).

. A. S. Madsen, C. Andersen, M. Daoud, K. A. Anderson, J. S. Laursen, S. Chakladar, A. R. Colaco, F. K. Huynh, D. S. Backos, P. Fristrup, M. D. Hirschey, C. A. Olsen. Investigating the Sensitivity of NAD+-Dependent Sirtuin Deacylation to NADH. J. Biol. Chem. 2016, 291, 7128–7141.

. I. Galleano, M. Schiedel, M. Jung, A. S. Madsen, C. A. Olsen. A Continuous, Fluorogenic Sirtuin 2 Deacylase Assay: Substrate Screening and Inhibitor Evaluation. J. Med. Chem. 2016, 59, 1021–1031.

M. Baldry, H. Frøkiær, B. Kitir, S. B. Christensen, N. Taverne, M. Meijerink, H. Franzyk, C. A. Olsen, J. M. Wells, H. Ingmer. Solonamide B and Analogues are not Toxic and do not Interfere with Host Immunity During Anti-Virulence Activity Against Staphylococcus aureus. PloS ONE 2016, 11(1), e0145618.

51. A. S. Madsen, C. A. Olsen. A Potent Trifluoromethyl Ketone Histone Deacetylase Inhibitor Exhibits Class-dependent Mechanism of Action. Med. Chem. Commun. 2016, 7, 464–470. (Special issue, New Talent: Europe).

J. S. Laursen, J. Engel-Andreasen, C. A. Olsen. β-Peptoid Foldamers at Last. Acc. Chem. Res. 2015, 48, 2696–2704.

J. S. Laursen, P. Harris, P. Fristrup, C. A. Olsen. Triangular Prism-Shaped beta-Peptoid Helices as Unique Biomimetic Scaffolds. Nat. Commun. 2015, 6, 7013.

J. Engel-Andreasen, K. Wich, J. S. Laursen, P. Harris, C. A. Olsen. Effects of Thionation and Fluorination on Cis–Trans Isomerization in Tertiary Amides: An Investigation of N-Alkylglycine (Peptoid) Rotamers. J. Org. Chem. 2015, 80, 5415–5427. (Selected for Cover Art).

47. K. Andreev, C. Bianchi, J. S. Laursen, L. Citterio, L. Hein-Kristensen, L. Gram, I. Kuzmenko, C. A. Olsen, D. Gidalevitz. Guanidino Groups Greatly Enhance the Action of Antimicrobial Peptidomimetics Against Lipid Monolayers Mimicking Gram-positive Bacteria Membranes. Biochim. Biophys. Acta Biomembr. 2014, 1838 , 2492–2502.

46. A. R. Maolanon,# J. S. Villadsen,# N. J. Christensen, C. Hoeck, T. Friis, P. Harris, C. H. Gotfredsen, P. Fristrup, C. A. Olsen. Methyl Effect in Azumamides Provides Insight Into Histone Deacetylase Inhibition by Macrocycles. J. Med. Chem. 2014, 57, 9644–9657.

B. Kitir, M. Baldry, H. Ingmer, C. A. Olsen.* Total Synthesis and Structural Validation of Cyclodepsipeptides Solonamide A and B. Tetrahedron 2014, 70, 7721–7732. (Symposium-in-Print on Peptide Macrocycles).

J. S. Villadsen, B. Kitir, K. Wich, T. Friis, A. S. Madsen, C. A. Olsen.* A Macrocyclic Azumamide Analogue without the Zinc-Binding Functionality. Med. Chem. Commun. 2014, 5, 1849–1855. (Special issue on epigenetics).

M. Tan, C. Peng, K. A. Anderson, P. Chhoy, Z. Xie, L. Dai, J. S. Park, Y. Chen, H. Huang, Y. Zhang, J. Ro, G. R. Wagner, M. F. Green, A. S. Madsen, J. Schmiesing, B. S. Peterson, G. Xu, O. R. Ilkayeva, M. J. Muehlbauer, T. Braulke, C. Mühlhausen, D. S. Backos, C. A. Olsen, P. J. McGuire, S. D. Pletcher, D. B. Lombard, M. D. Hirschey, Y. Zhao. Lysine Glutarylation Is a Protein Modification Regulated by SIRT5. Cell Metab. 2014, 19, 605–617. (Free Featured Article). 

42. C. A. Olsen.* An Update on Lysine Deacylases Targeting the Expanding “Acylome”. ChemMedChem. 2014, 9, 434–437. (Invited contribution for special issue on epigenetics).

41. A. S. Madsen, H. M. E. Kristensen, G. Lanz, C. A. Olsen.* The Effect of Various Zinc Binding Groups on Inhibition of Histone Deacetylases 1–11. ChemMedChem. 2014, 9, 614–626. (Invited contribution for special issue on epigenetics, Back Cover, Spotlight in Angew. Chem. Int. Ed. 2014, 53, 3055).

J. S. Villadsen, H. M. Stephansen, A. R. Maolanon, P. Harris, C. A. Olsen.* Total Synthesis and Full Histone Deacetylase Inhibitory Profiling of Azumamide A–E as Well as beta2-Epi-Azumamide E and beta3-Epi-Azumamide. J. Med. Chem. 2013, 56, 6512–6520.

39. J. S. Laursen, J. Engel-Andreasen, P. Fristrup, P. Harris, C. A. Olsen.* Cis–Trans Amide Bond Rotamers in beta-Peptoids and Peptoids: Evaluation of Stereoelectronic Effects in Backbone and Side Chains. J. Am. Chem. Soc. 2013, 135, 2835–2844.

A. S. Madsen, C. A. Olsen.* Profiling of Substrates for the Zinc-Dependent Lysine Deacylase Enzymes: HDAC3 Exhibits Decrotonylase Activity In Vitro. Angew. Chem. Int. Ed. 2012, 51, 9083–9087.

A. S. Madsen, C. A. Olsen.* Substrates for Efficient Fluorometric Screening Employing the NAD-Dependent Sirtuin 5 Lysine Deacylase (KDAC) Enzyme. J. Med. Chem. 2012, 55, 5582–5590.

A. N. Hansen, C. D. Bendiksen, L. Sylvest, T. Friis, D. Staerk, F. S. Jørgensen, C. A. Olsen,* G. Houen.* Synthesis and Antiangiogenic Activity of N-alkylated Levamisole Derivatives. PLoS ONE, 2012 , 7(9), e45405.

35. C. A. Olsen.* Expansion of the Lysine Acylation Landscape. Angew. Chem. Int. Ed. 2012, 51, 3755–3756.

Postdoctoral and Assistant Professor publications

34. C. A. Olsen, A. Montero, L. J. Leman, M. R. Ghadiri. Macrocyclic Peptoid–Peptide Hybrids as Inhibitors of Class I Histone Deacetylases. ACS Med. Chem. Lett20123, 749–753.

33. C. J. Vickers, C. A. Olsen, L. J. Leman, M. R. Ghadiri. Discovery of HDAC Inhibitors that Lack an Active Site Zn2+-Binding Functional Group. ACS Med. Chem. Lett20123, 505–508. (Top five downloaded Letter in May and June 2012, selected for the Cover of April 2013 issue).

32. C. A. Olsen, A. S. Kristensen, K. Strømgaard. Small Molecules from Spiders Used as Chemical Probes. Angew. Chem. Int. Ed. 2011, 50, 11296–11311. (Review).

31. D. A. Hutt,† C. A. Olsen,† C. J. Vickers, D. Herman, M. Chalfant, A. Montero, L. J. Leman, R. Burkle, B. E. Maryanoff, W. E. Balch, M. R. Ghadiri. Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of deltaF508-CFTR. ACS Med. Chem. Lett. 2011, 2, 703–707. (†co-first author).

30. C. A. Olsen.* beta-Peptoid “Foldamers” – Why the Additional Methylene Unit? Biopolymers (Pept. Sci.) 2011, 96, 561–566.

29. S. Frølund, A. Bella, A. S. Kristensen, H. L. Ziegler, M. Witt, C. A. Olsen, K. Strømgaard, H. Franzyk, J. W. Jaroszewski. Assessment of Structurally Diverse Philanthotoxin Analogues for Inhibitory Activity on AMPA and NMDA Ionotropic Glutamate Receptor Subtypes: Discovery of Nanomolar, Non-Selective, and Use-Dependent Antagonists. J. Med. Chem. 2010, 53, 7441–7451.

28. C. A. Olsen,* H. L. Ziegler, H. M. Nielsen, N. Frimodt-Møller, J. W. Jaroszewski, H. Franzyk. Antimicrobial, Hemolytic, and Cytotoxic Activities of beta-Peptoid–Peptide Hybrid Oligomers: Improved Properties Compared to Natural AMPs. ChemBioChem. 2010, 11, 1356–1360. (Inside Cover).

27. C. A. Olsen.* Peptoid–Peptide Hybrid Backbone Architectures. ChemBioChem. 2010, 11, 152–160. (Review article, Inside Cover, Spotlight in Angew. Chem. Int. Ed. 2010, 49, 836).

26. C. A. Olsen, M. R. Ghadiri. Discovery of Potent and Selective Histone Deacetylase Inhibitors via Focused Combinatorial Libraries of Cyclic alpha3beta-Tetrapeptides. J. Med. Chem. 2009, 52, 7836–7846.

25. W. S. Horne,† C. A. Olsen,† J. M. Beierle, A. Montero, M. R. Ghadiri. Probing the Bioactive Conformation of an Archetypal Natural Product HDAC Inhibitor Using Conformationally Homogeneous Triazole-Modified Cyclic Tetrapeptides. Angew. Chem. Int. Ed. 2009, 48, 4718–4724. (†co-first author, Frontispiece, Highlighted in Nat. Chem. Biol. 2009, 5, 280).

24. A. Montero, J. M. Beierle, C. A. Olsen, M. R. Ghadiri. Design, Synthesis, Biological Evaluation, and Structural Characterization of Potent Histone Deacetylase Inhibitors Based on Cyclic alpha/beta-Tetrapeptide Architectures. J. Am. Chem. Soc. 2009, 131, 3033–3041.

23. L. K. Ottesen, C. A. Olsen, M. Witt, J. W. Jaroszewski, H. Franzyk. Selectively N-Protected Enantiopure 2,5-Disubstituted Piperazines: Avoiding the Pitfalls in Solid-Phase Fukuyama-Mitsunobu Cyclizations. Chem.–Eur. J. 2009, 15, 2966–2978.

22. C. Foged, H. Franzyk, S. Bahrami, S. Frokjaer, J. W. Jaroszewski, H. M. Nielsen, C. A. Olsen. Cellular Uptake and Membrane-Destabilizing Properties of α-peptide/β-Peptoid Chimeras: Lessons for the Design of New Cell-Penetrating Peptides. Biochim. Biophys. Acta. 2008, 1778, 2487–2495.

21. G. Bonke, L. Vedel, M. Witt, J. W. Jaroszewski, C. A. Olsen,* H. Franzyk.* Dimeric Building Blocks for Solid-Phase Synthesis of α-peptide/β-Peptoid Chimeras. Synthesis. 2008, 2381–2390.

20. C. A. Olsen,* M. Lambert, M. Witt, H. Franzyk, J. W. Jaroszewski.. Solid-Phase Peptide Synthesis and Circular Dichroism Study of Chiral β-Peptoid Homooligomers. Amino Acids. 2008, 34, 465–471.

19. L. Vedel, G. Bonke, C. Foged, H. Ziegler, H. Franzyk, J. W. Jaroszewski, C. A. Olsen.* Antiplasmodial and Prehemolytic Activities of α-peptide/β-Peptoid Chimeras. ChemBioChem. 2007, 8, 1781–1784.

18. C. A. Olsen,* G. Bonke, L. Vedel, A. Adsersen, M. Witt, H. Franzyk, J. W. Jaroszewski. α-peptide/β-Peptoid Chimeras. Org. Lett. 2007, 9, 1549–1552.

17. C. A. Olsen,* H. Franzyk, J. W. Jaroszewski. Aziridines in Parallel- and Solid-Phase Synthesis. Eur. J. Org. Chem. 2007, 1717–1724. (Review).

16. C. A. Olsen,* M. Witt, H. Franzyk, J. W. Jaroszewski. Solid-Phase Synthesis of Neuroactive Spider-Wasp Hybrid Toxin Analogues using a Backbone Amide Linker. Tetrahedron Lett. 2007, 48, 405–408.

15. C. A. Olsen,* C. Christensen, B. Nielsen, F. M. Mohamed, M. Witt, R. P. Clausen, J. L. Kristensen, J. W. Jaroszewski, H. Franzyk. Aminolysis of Resin-Bound N-Nosylaziridine-2-carboxylic Acids. Org. Lett, 2006, 8, 3371–3374.

Graduate publications

14. K. Strømgaard, L. Piazzi, C. A. Olsen, H. Franzyk, J. W. Jaroszewski. Protolytic Properties of Polyamine Wasp Toxin Analogues Studied by 13C NMR Spectroscopy. Magn. Res. Chem. 2006, 44, 1013–1022.

13. D. Pla, A. Marchal, C. A. Olsen, A. Francesch, C. Cuevas, F. Albericio, M. Álvarez. Synthesis and Structure–Activity Relationship Study of Potent Cytotoxic Analogues of the Marine Alkaloid Lamellarin D. J. Med. Chem. 2006, 49, 3257–3268.

12. C. A. Olsen, I. R Mellor, P. Wellendorph, P. N. R. Usherwood, M. Witt, H. Franzyk, J. W. Jaroszewski. Tuning Wasp Toxin Structure for Nicotinic Receptor Antagonism: Cyclohexylalanine-Containing Analogues as Potent and Voltage-Dependent Blockers. ChemMedChem. 2006, 1, 303–305. (Cover graphics).

11. C. A. Olsen,* M. Witt, S. H. Hansen, J. W. Jaroszewski, H. Franzyk. Fukuyama-Mitsunobu Alkylation in Amine Synthesis on Solid Phase Revisited: N-Alkylation with Secondary Alcohols and Synthesis of Curtatoxins. Tetrahedron. 2005, 61, 6046–6055.

10. C. A. Olsen, M. R. Jørgensen, S. H. Hansen, M. Witt, J. W. Jaroszewski, H. Franzyk. Side-Chain Anchored N-Fmoc-Tyr-OPfp for Bidirectional Solid-Phase Synthesis. Org. Lett. 2005, 7, 1707–1721.

9. M. R. Jørgensen, C. A. Olsen, I. R Mellor, P. N. R. Usherwood, M. Witt, J. W. Jaroszewski, H. Franzyk. Philanthotoxin Analogues: The Effect of Conformational Constraints and Steric Bulk in the Amino Acid Moiety of Philanthotoxins on AMPAR Antagonism. J. Med. Chem. 2005, 48, 56–70.

8. D. Pla, A. Marchal, C. A. Olsen, F. Albericio, M. Álvarez. Modular Total Synthesis of Lamellarin D. J. Org. Chem. 2005, 70, 8231–8234.

7. C. A. Olsen, N. Parera, F. Albericio, M. Álvarez. 5,6-Dihydropyrrolo[2,1-b]isoquinolines as Scaffolds for Synthesis of Lamellarin Analogues. Tetrahedron Lett. 2005, 46, 2041–2044.

6. C. A. Olsen,* H. Franzyk, J. W. Jaroszewski. N-Alkylation and Indirect Formation of Amino Functionalities in Solid-Phase Synthesis. Synthesis. 2005, 2631–2653. (Review).

5. C. A. Olsen, M. Witt, J. W. Jaroszewski, H. Franzyk. Expedient Protocol for Solid-Phase Synthesis of Secondary and Tertiary Amines. Org. Lett. 2004, 6, 1935–1938.

4. C. A. Olsen, M. Witt, J. W. Jaroszewski, H. Franzyk. Solid-Phase Synthesis of Acylpolyamines using Temporary N-4,4'-Dimethoxytrityl Protection in the Presence of Trityl Linkers. J. Org. Chem. 2004, 69, 6149–6152.

3. C. A. Olsen, M. Witt, J. W. Jaroszewski, H. Franzyk. Diols as Building Blocks in Solid-Phase Synthesis of Polyamine Toxins by Fukuyama-Mitsunobu Alkylation. Synlett. 2004, 473–476.

2. C. A. Olsen, M. Witt, J. W. Jaroszewski, H. Franzyk. Solid-phase Polyamine Synthesis using Piperazine and Piperidine Building Blocks. Org. Lett. 2003, 5, 4183–4185.

1. C. A. Olsen, M. R. Jørgensen, M. Witt, I. R. Mellor, P. N. R. Usherwood, J. W. Jaroszewski, H. Franzyk. The Choice of Phosphane Reagent in Fukuyama-Mitsunobu Alkylation: Intramolecular Selectivity Between Primary and Secondary Alcohols in the Preparation of Asymmetric Tetramine Building Blocks for Synthesis of Philanthotoxins Eur. J. Org. Chem. 2003, 3288–3299.

Other activities

Participation in the DR2 TV program ”Danskernes Akademi” (Autumn 2011).

Article in DTU-Avisen about the Lundbeck Junior Group Leader project (December 2010).

Participation in an interview regarding Lundbeck Junior Group Leader Fellowship project in the TV2 talk show Lounge (Autumn 2010).

An interview on postdoc project at TSRI was published in the annual report of the Danish Research Council for Technology and Production Sciences (Autumn 2008).

C. A. Olsen, Interessante egenskaber ved nye peptidmimiks indeholdende unaturlige β-peptoid enheder. Dansk Kemi. 2008, 89(2), 33-35.

C. A. Olsen, H. Franzyk, J. W. Jaroszewski, Kunstige forsvarspeptider – en ny måde at dræbe bakterier på. Lægemiddelforskning (DFU). 2006, 19-20.

C. A. Olsen, H. Franzyk, J. W. Jaroszewski, Nanomolær Inhibering med Hvepsetoksinanaloger – Syntese og Elektrofysiologi. Dansk Kemi. 2006, 87(6/7), 23-26.