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Welcome to the Olsen laboratory
With a foundation in chemical synthesis, we seek to explore the function of small molecules, peptides, peptidomimetics, and proteins in biological systems. We are focusing on peptidomimetic secondary structures with potential as antimicrobial agents, as non-proteinogenic ligands for disruption of protein–protein interactions, and for multivalent display. We are also exploring naturally occurring macrocyclic peptides – and analogues thereof – for development of class- or isoform-selective HDAC inhibitors and quorum sensing modulators, as well as investigating substrate-specificity of the human lysine deacylase enzymes using chemical biology tools.
Funding and affiliations
We gratefully acknowledge the generous financial support from the following:
January, We thank the Carlsberg Foundation for funding equipment to start doing electrochemistry in the lab. Kudos to Bengt for writing this proposal!
December, We are happy to share work from Nima and Alexander on "Considerations for Drug Design using Mechanism-based Sirtuin Inhibition" via ChemRxiv 2019, DOI: 10.26434/chemrxiv.11339774.v1).
November, We can finally report on our new design strategy for activity-based probes to investigate lysine acylation. Available at ChemRxiv 2019, DOI: 10.26434/chemrxiv.10315502. Congratulations on the massive achievement Michael et al.
Olsen lab outing September 2019