Welcome to the Strømgaard Laboratory
The Strømgaard lab studies integral membrane protein and associated protein-protein interactions. We are combining tools from chemistry and biology to provide molecular-level insight into the functions and mechanisms of therapeutically relevant membrane proteins, and their interaction with intracellular protein partners. Key areas of interest are membrane proteins such as the serotonin transporter (SERT), a primary target in depression, and intracellular signaling proteins such as PSD-95, an emerging target in stroke.
We combine both site-directed and unnatural mutagenesis, with medicinal chemistry to study molecular details of how neurotransmitter transporters function. Examples include delineation of molecular details of how antidepressants such as escitalopram (Lexapro) and fluoxetine (Prozac) inhibit SERT and the first demonstration of introduction of unnatural amino acids into SERT.
We combine solid-phase peptide synthesis and organic chemical synthesis, with protein expression, biochemical and biophysical assays to examine protein-protein interactions. Examples include development of multimeric peptide-based inhibitors of PSD-95 and introduction of post-translational modifications and backbone modifications by protein semisynthesis.